Fine-Tuning of Molecular Structures to Generate Carbohydrate Based Super Gelators and Their Applications for Drug Delivery and Dye Absorption

Carbohydrate-based low molecular weight gelators (LMWGs) exhibit many desirable properties making them useful in various fields including applications as drug delivery carriers. In order to further understand the structural connection gelation properties, especially influence of halide substitutions, we have designed and synthesized a series para-chlorobenzylidene acetal protected D-glucosamine amide derivatives. Fifteen different amides were synthesized, their self-assembling assessed multiple organic solvents, well mixtures solvents with water. All derivatives found be for at least one solvent majority formed gels concentrations lower than 2 wt%. A few rendered remarkably stable aqueous solutions below 0.1 The benzamide 13 water EtOH/H2O (v/v 1:2) 0.36 mg/mL. characterized using optical microscopy atomic force microscopy, self-assembly mechanism was probed variable temperature 1H-NMR spectroscopy. Gel extrusion studies H2O/DMSO successfully printed lines on glass slides, which retained viscoelasticity based rheology. Gels by used encapsulation controlled release chloramphenicol naproxen, dye removal toluidine blue solutions.